Platform Features
Enterprise B2B Decision Support System (DSS) for Pharmaceutical Compounding & Solid Dosage Simulation
Visual, Instant & Cloud-Based
Traditional pharmaceutical R&D software is like AutoCAD—heavy, desktop-bound, expensive, and requires a PhD in computational chemistry. PharmNode Studio is the Canva for formulators. Run calculations in your browser, drag and drop components, and map active substances, binders, and excipients in seconds.
Key Value Propositions
Virtual Lab in Your Browser for $39/mo
Replace heavy molecular modeling suites costing $20,000/year per seat with a lightweight, high-performance SaaS. Perfect for contract manufacturing sites (CDMO), startup labs, and dietary supplement brands.
Prevent Chemical Conflicts Before the First Lab Run
Save thousands of dollars on wasted raw materials and weeks of failed experimental batches. screen formulations digitally and test only the viable candidates.
Scientific Core & Computational Engine
Under the hood of our real-time simulation engine
1. Node-Based Formulation Canvas
Construct complex multi-ingredient formulations visually. Connect active ingredients (API), fillers, binders, and lubricants using standard drag-and-drop nodes. The flow of data is computed dynamically: any changes in raw materials propagate instantly down the line to blending, pressing, and final output nodes. The visual node canvas ensures absolute conceptual clarity for R&D teams.
2. Computational Powder Flowability Simulator
PharmNode automatically calculates Carr's Index and Hausner's Ratio with 4 decimal places of accuracy to ensure dry powder mixtures maintain optimal flowability. The engine prevents tableting issues like capping, lamination, and weight variation by monitoring raw material properties.
Mathematical Models Executed:
Carr's Index (C) measures compressibility and predicts flowability classification:
Hausner's Ratio (H) characterizes flow properties and cohesiveness:
Recommended Tablet Weight (W_rec) represents 90% of theoretical die cavity capacity:
Where \rho_b is loose bulk density (g/mL), \rho_t is tapped density (g/mL), and V_die is the fill volume (cm³).
3. Rule-Based Chemical Compatibility Screen
PharmNode contains a rule-based expert system mapping chemical classes to detect formulation conflicts instantly. Unlike standard spreadsheets that calculate formulas blindly, PharmNode analyzes interactions and lights up red or yellow connections on the canvas before any physical materials are mixed.
Key Chemical Conflicts Modeled:
Maillard Browning Reaction
Occurs when primary or secondary amines (e.g. certain active ingredients) are mixed with reducing sugars (such as lactose). In the presence of trace moisture, this results in dark brown degradation products and active substance loss.
Alkaline Lubricant Degradation
Alkaline lubricants (like Magnesium Stearate) create a local basic microenvironment, catalyzing the hydrolysis of amine-based compounds and degrading fat-soluble vitamins.
Acid-Base Gas Evolution
Mixing organic acids (e.g., Vitamin C) with carbonates or bicarbonates triggers carbon dioxide release under moisture, causing tablet swelling and physical fracturing.
4. Digital Quality by Design (QbCD)
Quality by Design (QbD) has historically been gatekept by expensive consulting and heavy compliance software. PharmNode democratizes QbCD. Test 10 virtual formulation hypotheses in one evening, discard 8 poor flowability or high-porosity variations, and send only the 2 top-performing options to the physical laboratory.
Tablet Porosity (P) Simulation:
We calculate tablet porosity to predict compaction strength and dissolution times:
Where \rho_apparent is the apparent density of the tablet (mass / volume), and \rho_true is the true skeletal density of the blend.
5. Regulatory-Compliant GMP PDF Reports
Generate professional reports containing complete formula logs, compatibility matrices, and calculated physical parameters. Designed in compliance with FDA 21 CFR Part 11 and EU GMP Annex 11, these reports allow digital signatures and validation notes to ensure seamless tech-transfer to production sites.
Competitive Landscape Matrix
How PharmNode compares to traditional corporate software classes
| Software Class | User Obstacles & Cost | The PharmNode Solution |
|---|---|---|
| Heavy Molecular Software (CADD) | Costs $10,000–$50,000/yr. Requires a PhD in computational chemistry. Focuses on atomic behavior, which is useless for practical compounding of supplement blends. | Operates at the practical formulation level (excipients, binders, APIs). Requires zero training, runs in the browser, and is affordable for small teams. |
| Digital CMC / PLM Databases | Clunky, slow databases designed for regulatory filing. Boring spreadsheets tailored for compliance officers rather than R&D engineers. | Interactive, node-based Canvas. Technologists drag-and-drop ingredients and immediately see physical properties change visually in real-time. |
| Design of Experiments (DoE) Software | Requires you to run 15-20 physical experiments, waste kilograms of expensive raw materials, and manually input results to draw graphs. | Works BEFORE the physical lab. The expert rules identify issues like Maillard browning or compaction failure before you buy a single gram of raw material. |
Feature Matrix & Subscription Tiers
Detailed breakdown of Hobby vs. Professional capabilities
| Feature | Hobby Tier | Professional Tier |
|---|---|---|
| Max Ingredients per Formula | 3 ingredients | Unlimited |
| Chemical Compatibility Checking | Basic (10 classes) | Advanced (35 classes) |
| Powder Flowability Calculations (Carr & Hausner) | Yes | Yes |
| Tablet Press Volume & Porosity Simulation | Yes | Yes |
| GMP PDF Report Export | No | Unlimited (with validator signatures) |
| Custom Excipient Database Additions | No | Unlimited |
| REST API Access | No | Yes (20ms target latency) |
| Customer Support | Community support | Priority B2B (24/7) |
Ready to Virtualize Your Formulation Workflow?
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